Analysis of tracer experiments in non-conservative steady-state systems
| Autor: | H. E. Hart |
|---|---|
| Rok vydání: | 1955 |
| Předmět: |
Pharmacology
Radioactive tracer Steady state Non conservative General Mathematics General Neuroscience Immunology General Medicine Mechanics General Biochemistry Genetics and Molecular Biology law.invention Computational Theory and Mathematics law TRACER Catenary Calculus General Agricultural and Biological Sciences Constant (mathematics) Compartment (pharmacokinetics) General Environmental Science Mathematics |
| Zdroj: | The Bulletin of Mathematical Biophysics. 17:87-94 |
| ISSN: | 1522-9602 0007-4985 |
| DOI: | 10.1007/bf02477986 |
| Popis: | A method is developed for finding the transfer and localization rates and the volumes ofN compartment steady-state biological systems from experimental results. It is shown that a complete solution for certain systems in which the rates and volumes remain constant and in which there is access to all compartments can be obtained by using a single radioactive tracer. The information obtainable from experiments wherein some compartments are not accessible is analyzed for mammillary and catenary systems. Conservative systems are handled as special cases in which the localization is zero while anisotropic membranes separating compartments are shown to introduce no additional mathematical difficulty whenever all compartments are accessible. The limitations on the use of this method of multi-compartment tracer analysis are briefly discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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