| Autor: |
Simona Signorini, Luisa Imberti, Valeria Bianchi, Alberto Albertini, Roberto Stellini, Silvia Pirovano, Simona Fiorentini |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
British Journal of Haematology. 110:434-437 |
| ISSN: |
0007-1048 |
| DOI: |
10.1046/j.1365-2141.2000.02166.x |
| Popis: |
We report that alpha/beta and gamma/delta T-cell repertoires of three patients with idiopathic CD4+ lymphocytopenia, who showed different clinical manifestations and outcomes over time, were highly restricted. The disruption of T-cell repertoires does not influence the susceptibility to infections: the first patient was unable to attain a protective response to mycobacterium, the second showed clinical improvement and the third did not develop opportunistic infections. These results indicate that idiopathic CD4+ lymphocytopenia could give rise to mono-/oligoclonal T-cell expansions, but the degree of repertoire disturbance is not indicative of the severity of disease progression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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