Pulmonary perfusion scintigraphy and survival in lung carcinoma patients treated with chemotherapy and radiotherapy
| Autor: | P. Chilingirov, N. Georgieva, E. Obretenov, G. Kalaydjiev, Katya Peeva |
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| Rok vydání: | 2015 |
| Předmět: |
Surgical resection
medicine.medical_specialty Chemotherapy medicine.diagnostic_test Computer science Perfusion index medicine.medical_treatment Advanced stage medicine.disease Scintigraphy Radiation therapy Lung perfusion scintigraphy medicine Carcinoma Radiology Stage (cooking) Lung cancer Perfusion Median survival |
| Zdroj: | Trakia Journal of Science. 13:121-130 |
| DOI: | 10.15547/tjs.2015.s.02.026 |
| Popis: | Purpose: The best treatment for lung cancer is a surgical resection. Patients in advanced stage are subject to chemotherapy and/or radiotherapy. Our aim is to evaluate whether the survival is related to perfusion index, stage and presence of radio and/or chemotherapy. Materials And Methods: We analyzed the follow-up of 125 patients (118 men and 7 women, 30-76 years of age) with lung perfusion scintigraphy made between years 1989 and 1998 until 2013. Fortythree patients have been treated by radio-chemotherapy and 82 by chemotherapy. Patients have been staged by TNM classification from II to IV clinical stage. Survival was calculated by the KaplanMeier method, and groups were compared by the Mantel-Cox Log Rank test. Results: Perfusion changes varied from impaired in different extent perfusion to lack of perfusion in one of the lungs. The Median survival of radio-chemotherapy treated patients with perfusion index of affected lung less than 49% was 10,5 months and with perfusion index greater than 49% was 18,4 months. The overall Median survival of radio-chemotherapy treated patients was 11,2 months. The median survival of chemotherapy treated patients with perfusion index of affected lung less than 49% was 7,9 months and with perfusion index greater than 49% was 4,4 months. The overall Median survival for chemotherapy treated patients was 6,9 months. Conclusion: Perfusion index and stage were not statistically significant factors for the survival of patients with radio-chemotherapy and chemotherapy. Overall radio-chemotherapy treated patients have better median survival than the median survival by stage |
| Databáze: | OpenAIRE |
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