A new family of orphan G protein-coupled receptors predominantly expressed in the brain1

Autor:	J. Grayson Richards, Volker Breu, Thomas Giller, Olivier Valdenaire, Anja Schweizer, Ali Ardati
Rok vydání:	1998
Předmět:	Endothelin receptor type A Biophysics Cell Biology Biology Biochemistry Endothelin 1 Molecular biology Neuron-derived orphan receptor 1 Structural Biology Interleukin-21 receptor ROR1 Genetics 5-HT5A receptor GABBR1 Molecular Biology G protein-coupled receptor
Zdroj:	FEBS Letters. 424:193-196
ISSN:	0014-5793
DOI:	10.1016/s0014-5793(98)00170-7
Popis:	The cloning of a cDNA encoding a G protein-coupled receptor homologous to the endothelin type B receptor, but unable to bind endothelin, was recently reported and termed ETBR-LP. We report here the isolation of a human cDNA encoding a receptor that is highly related to ETBR-LP and which was therefore termed ETBR-LP-2. Comparison of the two amino acid sequences revealed 68% overall homology and 48% identity. As is the case for ETBR-LP, the new receptor is strongly expressed in the human central nervous system (e.g. in cerebellar Bergmann glia, cerebral cortex, internal capsule fibers). Membranes of HEK-293 cells stably expressing ETBR-LP-2 did not bind endothelin-1, endothelin-2, endothelin-3, bombesin, cholecystokinin-8 or gastrin-releasing peptide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::e08021168ecdb409c0b2150673b6b080 https://doi.org/10.1016/s0014-5793(98)00170-7 Zobrazit plný text záznamu Plný text