| Popis: |
Sulphadimidine is used in the treatment of susceptible enteric bacteria that could cause enteritis and since piroxicam is a potent anti-inflammatory agent, it is co-administered with piroxicam intramuscularly. In view of this, effects of piroxicam on the pharmacokinetics of sulphadimidine were studied in West African Dwarf (WAD) goats. Twenty goats of both sexes, aged 1-year-old and weighing 10.4 ± 1.3 kg were divided into two groups of 10 each (5 males; 5 females) were administered 100 mg/kg body weight of sulphadimidine via right thigh muscle, whereas piroxicam (5 mg/kg) was administered to WAD goats (5 males; 5 females). Blood samples were collected over a range of time (0-192 hrs) and analyzed for presence of sulphadimidine. The results showed significant increase (p |
