Magnetocaloric effect for inducing hypothermia as new therapeutic strategy for stroke: A physical approach
| Autor: | Manuel Bañobre-López, Tomás Sobrino, Bárbara Argibay, Alba Vieites-Prado, José Castillo, Ramón Iglesias-Rey, José Rivas, Francisco Campos |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Health Toxicology and Mutagenesis Physical approach Biomedical Engineering New materials 02 engineering and technology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Artificial Intelligence medicine Magnetic refrigeration General Pharmacology Toxicology and Pharmaceutics Adiabatic process Stroke Therapeutic strategy General Immunology and Microbiology General Neuroscience General Medicine Hypothermia 021001 nanoscience & nanotechnology medicine.disease Anesthesia Magnet medicine.symptom 0210 nano-technology General Agricultural and Biological Sciences 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Journal of Applied Biomedicine. 15:33-38 |
| ISSN: | 1214-0287 1214-021X |
| DOI: | 10.1016/j.jab.2016.09.006 |
| Popis: | Hypothermia is an effective neuroprotective strategy for acute stroke. However, in clinical practice, the induction of hypothermia is achieved through the systemic reduction of body temperature (using thermal covers or endovascular cooling devices) which results in a complex system associated in many cases to side effects. Therefore, the aim of this study was to test the magnetocaloric effect as a potential new therapeutic strategy for stroke by means of an adiabatic magnetic refrigerator device. As a first approach, we have developed a simple device to evaluate in vitro the thermodynamic behavior of different concentrations of commercial gadolinium powder as a reference magnetocaloric material. The samples, properly thermally insulated, were cyclically magnetized and demagnetized at room temperature by 1 T permanent magnets in order to induce an adiabatic magnetic effect. Under the experimental conditions tested, results showed a maximun non-accumulative temperature variation of 0.2 °C, insufficient to carry out an effective hypothermia. This study allowed us to discuss about the use of new materials and strategies for further in vivo experiments. |
| Databáze: | OpenAIRE |
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