Transforming growth factor β receptor signaling restrains growth of pancreatic carcinoma cells
| Autor: | Zhiming Zhao, Hao Xi, Dabin Xu, Chenggang Li |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
endocrine system diseases biology Cell growth Chemistry Cancer General Medicine Transforming growth factor beta medicine.disease digestive system diseases β receptor Endocrinology Apoptosis Internal medicine Infusion method medicine Cancer research biology.protein Pancreatic carcinoma Transforming growth factor |
| Zdroj: | Tumor Biology. 36:7711-7716 |
| ISSN: | 1423-0380 1010-4283 |
| Popis: | Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant. Efficient control of cancer growth may substantially improve the survival of PDAC patients. However, no efficient treatments are so far available. Here, we inhibited transforming growth factor β (TGFβ) receptor signaling by overexpression of a key inhibitor of this pathway, SMAD7, in the mouse pancreas, using a recently developed intraductal infusion method. Overexpression of SMAD7 significantly increased growth of both implanted PDAC and PDAC by K-ras modification. Our data thus suggest that TGFβ receptor signaling restrains growth of PDAC, and modulation of TGFβ receptor signaling may be an effective treatment for PDAC. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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