Synthesis of a new polycyclic heterocyclic ring system. Part III. Benzo[b]imidazo[1,5-d][1,4]oxazepine-1,4(2H,5H)-diones
| Autor: | Ognyan I. Petrov, Mariana Gerova, Desislava V. Stanisheva |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Heterocyclic Communications. 23:23-27 |
| ISSN: | 2191-0197 0793-0283 |
| DOI: | 10.1515/hc-2016-0236 |
| Popis: | A series of novel tricyclic benzoxazepines with fused imidazolone ring was prepared in five steps starting from the corresponding benzoxazolones 1–3. The key to the reported synthetic approach is transformation of 3-(2-oxopropyl)-2(3H)-benzoxazolones 4–6 to 1-(2-hydroxyphenyl)-4-methyl-1,3-dihydro-2H-imidazol-2-ones 7–12, and their subsequent conversion to the phenoxyacetic acids 19–24, which were finally acylated in polyphosphoric acid to form the oxazepine ring. |
| Databáze: | OpenAIRE |
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