Synthesis, Characterization, and Phosphoesterase Activity of a Series of 4f- and 4d-Sandwich-Type Germanotungstates [(n-C4H9)4N]l/mH2[(M(H2O)3)(γ-GeW10O35)2] (M = CeIII, NdIII, GdIII, ErIII, l = 7; ZrIV, m = 6)
| Autor: | Elias Tanuhadi, Annette Rompel, Alexander Roller, Emir Al-Sayed, Donatella Verbanac, Hana Čipčić-Paljetak |
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| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Inorganic Chemistry. 59:14078-14084 |
| ISSN: | 1520-510X 0020-1669 |
| DOI: | 10.1021/acs.inorgchem.0c01852 |
| Popis: | We report on a family of five new 4f- and 4d-doped sandwich-type germanotungstates with the general formula [(n-C4H9)4N]l/mH2[(M(H2O)3)(γ-GeW10O35)2]·3(CH3)2CO [M(H2O)3(GeW10)2] (M = CeIII, NdIII, GdIII, ErIII, l = 7; ZrIV, m = 6), which have been synthesized at room temperature in an acetone-water mixture. Among the compound series, [Zr(H2O)3(GeW10)2]8-, which has been obtained in the presence of 30% H2O2, represents the first example of a 4d-substituted germanotungstate incorporating the intact dilacunary [γ-GeIVW10O36]8- building block. All compounds were characterized thoroughly in the solid state by single-crystal and powder X-ray diffraction (XRD), IR spectroscopy, thermogravimetric analysis (TGA), and elemental analysis and in solution by NMR and UV-vis spectroscopy. The phosphoesterase activity of [Ce(H2O)3(GeW10)2]9- and [Zr(H2O)3(GeW10)2]8- toward the model substrates 4-nitrophenyl phosphate (NPP) and O,O-dimethyl O-(4-nitrophenyl) phosphate (DMNP) was monitored with 1H- and 31P-NMR spectroscopy revealing an acceleration of the hydrolytic reaction by an order of magnitude (kcorr = 3.44 (±0.30) × 10-4 min-1 for [Ce(H2O)3(GeW10)2]9- and kcorr = 5.36 (±0.05) × 10-4 min-1 for [Zr(H2O)3(GeW10)2]8-) as compared to the uncatalyzed reaction (kuncat = 2.60 (±0.10) × 10-5 min-1). [Ce(H2O)3(GeW10)2]9- demonstrated improved antibacterial activity toward Moraxella catarrhalis (MIC 32 μg/mL), compared to the unsubstituted [GeW10O36]8- POM (MIC 64 μg/mL). |
| Databáze: | OpenAIRE |
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