| Popis: |
Antibodies to a feline oncornavirus-associated cell membrane antigen have been found in newborn kittens whose mothers had previously nursed litters of kittens injected with feline leukemia virus (FeLV). These antibodies, which were apparently obtained passively from the mother, seem to protect the kittens from the development of progressive tumors following the injection of various amounts of feline sarcoma virus (FSV). That these mothers were apparently able to passively transmit immunity suggests that they became infected with FeLV in a horizontal manner while nursing previous litters and resisted the development of progressive tumors, but mounted an immune response which resulted in the production of humoral antibody. It also suggests that some degree of cross-protection exists in vivo between the feline leukemia and sarcoma viruses used in this study. Des anticorps d'un antigene de la membrane cellulaire associe a un oncornavirus felin ont ete observes chez des chatons nouveau-nes dont les meres avaient deja eleve des portees qui avaient recu une injection de virus de la leucemie feline (VLFe). Ces anticorps, apparemment transmis de facon passive par la mere, semblent proteger les chatons contre le developpement des tumeurs apres l'injection de differentes quantites de virus du sarcome felin (VSF). Le fait que les meres puissent apparemment transmettre l'immunite de facon passive donne a penser qu'elles ont ete infectees horizontale-ment par le VLFe lorsqu'elles elevaient les portees precedentes, qu'elles ont resiste au developpement tumoral, mais qu'elles ont elabore une reponse immunitaire aboutissant a la production d'anticorps circulants. Il existerait donc une certaine protection croisee in vivo a l'egard des virus de la leucemie et du sarcome felins utilises pour la presente etude. |
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