P.1.006 Screening for rare variants in TMEM132D: a candidate gene from genome-wide association studies in anxiety disorders
| Autor: | Bertram Müller-Myhsok, Peter Weber, Angelika Erhardt, Elisabeth B. Binder, Monika Rex-Haffner, Carina Quast, Andre Altmann |
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| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
Genetics Candidate gene Panic disorder Single-nucleotide polymorphism Genome-wide association study Biology medicine.disease Psychiatry and Mental health Neurology Schizophrenia medicine Genetic predisposition Anxiety Pharmacology (medical) Neurology (clinical) medicine.symptom Biological Psychiatry Genetic association |
| Zdroj: | European Neuropsychopharmacology. 21:S6-S7 |
| ISSN: | 0924-977X |
| DOI: | 10.1016/s0924-977x(11)70007-4 |
| Popis: | The aetiology of anxiety disorders is known to be influenced by genetic factors. Genome-wide association studies revealed common intronic SNPs within the 831942 bp long transmembrane protein 132D gene (TMEM132D) located on chromosome 12 to be associated with panic disorder and anxiety-related phenotypes (Erhardt et al., 2010). Recent studies in autism and schizophrenia have shown that a combination of common as well as rare functional disease variants is important in the genetic susceptibility to psychiatric disorders (Alaerts, Del-Favero, 2009; Uher, 2009). Therefore the exonic regions and exon-intron junctions of TMEM132D were investigated to identify both common and rare genetic variants which might be associated with changes in gene function in anxiety disorders. Background |
| Databáze: | OpenAIRE |
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