| Autor: |
Hani A. Awad, Jason Ko, Joel R. Ross, Herbert Hurwitz, Bruce Klitzman |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Journal of Surgical Research. 129:251-259 |
| ISSN: |
0022-4804 |
| DOI: |
10.1016/j.jss.2005.05.006 |
| Popis: |
Background ZD6474 is an inhibitor of the VEGFR-2 receptor tyrosine kinase with additional activity against EGFR-1 receptor tyrosine kinases that has been shown to inhibit tumor growth and wound-induced neovascularization in pre-clinical studies and phase I clinical trials. The purpose of this study was to determine the effects of ZD6474 on breaking strength in a murine model of cutaneous wound healing. Materials and methods Balb/C mice were given ZD6474 (50 or 100 mg/kg p.o.) or vehicle starting 7 days before wounding. Two full-thickness incisions were made in each mouse and closed using suture. On post-wounding day 7 or 28, laser Doppler blood flow measurements were made, and the breaking strength of the wounded skin was determined. Microvessel density measurements were performed using computer image analysis of CD31-stained sections. Results Compared with controls, mice treated with ZD6474 showed a significantly reduced dose-dependent decline in breaking strength, both at POD 7 (P Conclusion In a murine model of wound healing, ZD6474 treatment did not prevent wound healing, but was associated with a reduced skin breaking strength compared with vehicle-treated controls at both 7 and 28 days post-wounding. These observations may have clinical relevance for the perioperative management of patients treated with inhibitors of angiogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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