ChemInform Abstract: A Facile Route to Functionalized Cyclopenta[b]thiophenones Based on the Structure of the Selective COX-2 Inhibitor Flosulide

Autor:	Dieter Binder, Roman Steindl, Martin Weisgram, Michael Pyerin
Rok vydání:	2010
Předmět:	Acylation chemistry.chemical_compound chemistry Nucleophilic aromatic substitution Nitration Thiophene COX-2 inhibitor General Medicine Alkylation Thiophene derivatives Combinatorial chemistry
Zdroj:	ChemInform. 30
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199901122
Popis:	The synthesis of three thiophene analogues of Flosulide – a potent and selective inhibitor of cyclooxygenase subtype 2 (COX-2) – is described. Utilizing combined Friedel-Crafts acylation and alkylation of 2-chlorothiophene, simplified procedures were developed to obtain cyclopenta[b]- thiophenones as key products which were further derivatized by nitration, nucleophilic aromatic substitution, reduction, and mesylation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::deb4bd05db0c3e61eab98916424139a7 https://doi.org/10.1002/chin.199901122 Zobrazit plný text záznamu Plný text