| Autor: |
Ghirga Piero, Di Caro Antonino, Murachelli Silvia, Gina Gualano, Rocco Urso, Biagioli Daniele, Lauria Francesco Nicola, Girardi Enrico, Rosati Silvia, Tonnarini Roberto, Palmieri Fabrizio, Matteucci Giuseppe, Biava Gianluigi, Ippolito Giuseppe, Goletti Delia |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
10.2 Tuberculosis. |
| DOI: |
10.1183/13993003.congress-2016.pa2688 |
| Popis: |
Background: MDR-TB is emerging as a major challenge for tuberculosis control programs.In Italy the proportion of MDR-TB reported during 2013 was 3.3%; unfortunately, treatment outcomes in MDR-TB patients are poorly documented. Aim: To evaluate the outcomes of MDR-TB patients treated at the National Institute of Infectious Disease (INMI), a referral hospital for Infectious Diseases in Italy. Methods: 74 MDR-TB patients diagnosed between 2008 and 2015 were consecutively enrolled in an observational retrospective cohort study. All patients were treated according WHO guidelines. Results: The patients (median age 35.8 yr) were mainly male (63.5%) and foreign born (87.2%). Among 74 patients, 2 were extensively drug-resistant (XDR) cases, 2 patients were HIV-coinfected,and 45 (61.0%) were newly diagnosed. Fifty-eight (78.4%) cases were pulmonary sputum smear-positive. 51% of patients were transferred in from units of other regions of central and southern Italy. Among 57 patients who completed treatment in the study period, 68.4 % achieved treatment success, 22.8% were lost to follow up, 3% were transferred out and 1.8% died. Conclusion: Monitoring the treatment outcome of MDR-TB is essential to evaluate the effectiveness of interventions and to identify potential barriers for TB control. In our cohort MDR-TB is mainly related to the immigration of patients from countries with a high TB prevalence with a high proportion of new cases. Data show that, in a referral center for the treatment of MDR-TB, success rates close to the target defined by WHO can be achieved, even if actions are required to reduce the high proportion of patients lost to follow-up. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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