Lewis Acid-Catalyzed Asymmetric Selenocyanation of β-Ketoesters with N-Selenocyanatosaccharin
Autor: | Hongquan Yin, Di Wu, Fu-Xue Chen, Chengqiu Li, Jiashen Qiu, Lexia Yuan |
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Rok vydání: | 2019 |
Předmět: | |
Zdroj: | The Journal of Organic Chemistry. 85:934-941 |
ISSN: | 1520-6904 0022-3263 |
Popis: | The first electrophilic asymmetric selenocyanation has been achieved in the presence of Ni(OTf)2 and (R,R)-DBFOX/Ph using N-selenocyanatosaccharin as the new selenocyanation reagent. Thus, a series of α-selenocyanato-β-keto esters were synthesized with high yields (up to 99%) and good ee values (up to 92% ee). The readily preparation of the reagent and high enantioselectivity make this methodology much practical for the synthesis of chiral selenocyanates. |
Databáze: | OpenAIRE |
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