Evidence for the Existence of Definitive Hepatic Cholesterol Precursor Compartments for Bile Acids and Biliary Cholesterol in Man
| Autor: | Leon Swell, J.B. Meek, Z.R. Vlahcevic, L.G. Halloran, Daniel H. Gregory, Charles C. Schwartz |
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| Rok vydání: | 1975 |
| Předmět: |
medicine.medical_specialty
Hepatology Bile acid Chemistry Cholesterol medicine.drug_class Gastroenterology Hepatic cholesterol Mevalonic acid Biliary cholesterol chemistry.chemical_compound Free cholesterol Endocrinology Plasma cholesterol Internal medicine medicine lipids (amino acids peptides and proteins) Constant infusion |
| Zdroj: | Gastroenterology. 69:1379-1382 |
| ISSN: | 0016-5085 |
| DOI: | 10.1016/s0016-5085(19)32342-x |
| Popis: | A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursorproduct relationship between biliary cholesterol, plasma free cholesterol and bile acids. Both the constant infusion and pulse labeling data indicated that the bile acid precursor had a more rapid rate of turnover than plasma or biliary cholesterol; the biliary cholesterol precursor turned over more rapidly than plasma cholesterol. The data suggest the presence of multiple hepatic cholesterol precursor compartments. Bile acids may be derived predominantly from newly synthesized cholesterol in man. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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