Synergistic effects of malononitrilamides (FK778, FK779) with tacrolimus (FK506) in prevention of acute heart and kidney allograft rejection and reversal of ongoing heart allograft rejection in the rat1
| Autor: | Shijie Qi, Jun Ouyang, Kupa K. Bilolo, Ihor Bekersky, Wenlei Jiang, Dasheng Xu, Huifang Chen, William E. Fitzsimmons, Xiang Wang, Shengyun Zhu, Marie J. Hebert |
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| Rok vydání: | 2003 |
| Předmět: |
Transplantation
Kidney Chemotherapy medicine.medical_specialty Combination therapy business.industry medicine.medical_treatment Urology chemical and pharmacologic phenomena medicine.disease Tacrolimus Surgery Calcineurin surgical procedures operative medicine.anatomical_structure Medicine business Kidney transplantation Heart allograft |
| Zdroj: | Transplantation. 75:1881-1887 |
| ISSN: | 0041-1337 |
| DOI: | 10.1097/01.tp.0000064710.78335.d3 |
| Popis: | Background The effects of tacrolimus (FK506) and malononitrilamides (MNA) (FK778 and FK779) monotherapy and combination therapy were examined in prevention of acute heart and kidney allograft rejection and reversal of ongoing acute heart allograft rejection in the rat. Methods. Brown Norway (RT1 n )-to-Lewis (RT1 1 ) and ACI (RT1 a )-to-Lewis (RT1 1 ) combinations were used, respectively, for heart and kidney transplantation models. Immunosuppressants were administered orally from day 1 to day 14 for preventing acute rejection and from day 4 to day 34 after transplantation for the reversal of ongoing acute rejection. Results. In the prevention of acute heart rejection model, recipient rats treated with monotherapy of tacrolimus or MNA (FK778, FK779) showed a dose-related prolongation of mean survival time (MST) compared with naive control rats (P |
| Databáze: | OpenAIRE |
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