Detection and measurement of low levels of prothrombin. Use of a procoagulant from venom

Autor:	B.R. Franza, D.L. Aronson
Rok vydání:	1976
Předmět:	Globulin biology Chemistry Venom Hematology Pharmacology biology.organism_classification Blood proteins Thrombin Echis carinatus Coagulation Clotting time hemic and lymphatic diseases Immunology biology.protein medicine Thromboplastin circulatory and respiratory physiology medicine.drug
Zdroj:	Thrombosis Research. 8:329-336
ISSN:	0049-3848
Popis:	The ability of a procoagulant fraction from the venom of the saw-scaled viper ( Echis carinatus sochureki ) to convert prothrombin to thrombin in the absence of Ca2+ or other cofactors was used as the basis of a sensitive test method for prothrombin. Incubation of a test sample with prothrombin-free human fibrinogen and the procoagulant fraction resulted in clotting if prothrombin was present in the test sample; clotting time was a function of the amount of prothrombin over the range 0.02 – 1.0 unit. The test method appears valuable for detecting and quantitating low levels of prothrombin contamination in therapeutic products and in laboratory preparations of coagulation factors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd2a3078688274cdae02aeb2cea18427 https://doi.org/10.1016/0049-3848(76)90026-8 Zobrazit plný text záznamu