Raman spectroscopic characterization of anti-diabetic drug metformin hydrochloride

Autor:	V. N. Anisimov, B. H. Bairamov, F. B. Bayramov, V. Yu Rud, V. V. Toporov, O. B. Chakchir, Alexey Glinushkin
Rok vydání:	2019
Předmět:	Drug History business.industry media_common.quotation_subject Metformin Hydrochloride Computer Science Applications Education symbols.namesake symbols Medicine business Raman spectroscopy media_common Nuclear chemistry
Zdroj:	Journal of Physics: Conference Series. 1400:033010
ISSN:	1742-6596 1742-6588
DOI:	10.1088/1742-6596/1400/3/033010
Popis:	Raman scattering spectra of metformin hydrochloride, one of the most widely used oral anti-diabetic drugs which also possesses anti-aging and anti-tumor properties, have been obtained by high-resolution and high-sensitivity Raman-scattering technique. It is established that rather narrow (4–10 cm–1) spectral lines of molecular vibrations are observed in of the metformin hydrochloride pressed powder sample in the important spectral range of 50–1700 cm–1. These “fingerprints” can be applied to reveal which chemical bonds produce spectral components corresponding to the vibrations of particular functional groups and the presence of crystalline state of the metformin hydrochloride without evidence of an amorphous phase. This observation makes the metformin hydrochloride as promising model system for development and application as molecular biosensors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd1526c3363ce655a2ccd3e6880c0006 https://doi.org/10.1088/1742-6596/1400/3/033010 Zobrazit plný text záznamu