Crystal Engineering of the Composition of Pharmaceutical Phases: Multiple-Component Crystalline Solids Involving Carbamazepine

Autor:	Nair Rodriguez-Hornedo, Brian Moulton, Jennifer A. McMahon, Rosa D. Bailey Walsh, Srinivasan S. Kuduva, Scott G. Fleischman, Michael J. Zaworotko
Rok vydání:	2003
Předmět:	Formamide Formic acid medicine.drug_class Dimer Supramolecular chemistry Carboxamide General Chemistry Condensed Matter Physics Crystal engineering Combinatorial chemistry Cocrystal chemistry.chemical_compound chemistry medicine Organic chemistry General Materials Science Trimesic acid
Zdroj:	Crystal Growth & Design. 3:909-919
ISSN:	1528-7505 1528-7483
DOI:	10.1021/cg034035x
Popis:	The crystal engineering design strategy facilitates supramolecular synthesis of 13 new crystalline phases of carbamazepine (CBZ), an analgesic and anticonvulsant with known problems related to solubility and polymorphism. CBZ forms supramolecular complexes with the following molecules, all of which are complementary to CBZ in terms of hydrogen bonding and can therefore act as cocrystal formers: acetone (1a); DMSO (1b); benzoquinone (1c); terephthalaldehyde (1d); saccharin (1e); nicotinamide (1f); acetic acid (1g); formic acid (1h); butyric acid (1i); trimesic acid (1j); 5-nitroisophthalic acid (1k); adamantane-1,3,5,7-tetracarboxylic acid (1l); and formamide (1m). Two distinct strategies based upon selection of complementary hydrogen-bond functionalities and previously known supramolecular synthons were utilized: strategy I exploits the exofunctional nature of the carboxamide dimer as either a hydrogen-bond donor or a hydrogen-bond acceptor and thereby retains the carboxamide dimer that is present in al...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dd0182d98879afa2233c048619d177f1 https://doi.org/10.1021/cg034035x Zobrazit plný text záznamu