New monoterpenes from stalks and infructescence of Sibiraea leavigata

Autor:	Yanduo Tao, Shuo Wang, Yan-Ming Wang, Li-Juan Mei, Jian-Qiang Zhao, Jun-Jiang Lv
Rok vydání:	2016
Předmět:	Circular dichroism 010405 organic chemistry Stereochemistry Chemistry Plant Science 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Infructescence Ic50 values Cytotoxicity Agronomy and Crop Science Biotechnology
Zdroj:	Phytochemistry Letters. 18:1-4
ISSN:	1874-3900
DOI:	10.1016/j.phytol.2016.08.016
Popis:	Chemical investigation of the ethanol extract of the stalks and infructescence of Sibiraea leavigata led to the isolation of two new monoterpenes named (4R)-2-(2-hydroxy-4-methyl-3-pentenyl)furan-2(5H)-one (1) and (2R,4R)-2-(2-hydroxyethyl)-4-(2-methyl-1-propenyl)furan-5H-2-one (2) along with eight known phenylpropanoids (3–10). Their structures were established on the basis of the interpretation of spectroscopic data and electronic circular dichroism (ECD) calculations. In addition, all of these isolates were evaluated for their cytotoxic activity. The results showed that compound 3 displayed moderate cytotoxicity with IC50 values ranging from 10.8 to 49.2 μg mL−1 against five cell lines. While 1 showed selective promotion effects on proliferation of gastric cancer MGC803 and RSC96 cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dceba7ab15800bbd02c8798cb912f23f https://doi.org/10.1016/j.phytol.2016.08.016 Zobrazit plný text záznamu Full Text from ScienceDirect