Myeloid marker S100A8/A9 and lymphocyte marker, soluble interleukin 2 receptor: biomarkers of hidradenitis suppurativa disease activity?
| Autor: | J. Hessels, J.M. Rensen, H.G.M. Vloedgraven, Catharina W. Wieland, Johannes Roth, J. Boer, A. Ordelman, Thomas Vogl, L.H.A. Verwoolde |
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| Rok vydání: | 2013 |
| Předmět: |
Interleukin 2
medicine.medical_specialty Myeloid business.industry Lymphocyte Dermatology Disease medicine.disease Gastroenterology S100A8 chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine Immunology medicine Hidradenitis suppurativa Lysozyme Calprotectin business medicine.drug |
| Zdroj: | British Journal of Dermatology. 168:1252-1258 |
| ISSN: | 0007-0963 |
| DOI: | 10.1111/bjd.12234 |
| Popis: | Background Hidradenitis suppurativa (HS) is a chronic inflammatory and debilitating disease of the skin. No biomarkers for this disease exist. Objectives We set out to test whether angiotensin-converting enzyme (ACE), lysozyme, soluble interleukin 2 receptor (sIL-2R) and S100A8 ⁄A9 (calprotectin) are elevated in patients with HS. Methods Serum was collected from 29 patients with HS at different stages of the disease, and from 51 controls. ACE, lysozyme, sIL-2R and S100A8 ⁄A9 levels were measured. Clinical observation of disease activity was scored according to the Hurley grading system and by a physician global score (PGS) of disease severity. Results Serum levels of lysozyme and ACE were not increased above the normal reference values in controls or patients with HS. Levels of sIL-2R and S100A8 ⁄A9 were significantly higher in patients with HS than in controls (P |
| Databáze: | OpenAIRE |
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