Transcranial Photobiomodulation For The Management Of Depression: Current Perspectives
| Autor: | Paula Askalsky, Dan V. Iosifescu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry fungi chemical and pharmacologic phenomena medicine.disease Neuromodulation (medicine) 030227 psychiatry 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Mitochondrial respiratory chain Tolerability Animal models of depression medicine Major depressive disorder Antidepressant medicine.symptom business Suicidal ideation 030217 neurology & neurosurgery Management of depression |
| Zdroj: | Neuropsychiatric Disease and Treatment. 15:3255-3272 |
| ISSN: | 1178-2021 |
| DOI: | 10.2147/ndt.s188906 |
| Popis: | Major depressive disorder (MDD) is a prevalent condition associated with high rates of disability, as well as suicidal ideation and behavior. Current treatments for MDD have significant limitations in efficacy and side effect burden. FDA-approved devices for MDD are burdensome (due to repeated in-office procedures) and are most suitable for severely ill subjects. There is a critical need for device-based treatments in MDD that are efficacious, well-tolerated, and easy to use. In this paper, we review a novel neuromodulation strategy, transcranial photobiomodulation (t-PBM) with near-infrared light (NIR). The scope of our review includes the known biological mechanisms of t-PBM, as well as its efficacy in animal models of depression and in patients with MDD. Theoretically, t-PBM penetrates into the cerebral cortex, stimulating the mitochondrial respiratory chain, and also significantly increases cerebral blood flow. Animal and human studies, using a variety of t-PBM settings and experimental models, suggest that t-PBM may have significant efficacy and good tolerability in MDD. In aggregate, these data support the need for large confirmatory studies for t-PBM as a novel, likely safe, and easy-to-administer antidepressant treatment. |
| Databáze: | OpenAIRE |
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