Common Preconditions for Safe Phage Therapy of Pseudomonas aeruginosa Infections

Autor:	O. Polygach, Maria Bourkaltseva, Victor N. Krylov, E. Chesnokova, S. V. Krylov, O. V. Shaburova, E. A. Pleteneva
Rok vydání:	2014
Předmět:	Drug Phage therapy Pseudomonas aeruginosa viruses medicine.medical_treatment media_common.quotation_subject General Medicine Biology medicine.disease_cause Microbiology Eastern european Pseudomonas aeruginosa Infections medicine Bacterial virus media_common
Zdroj:	Advances in Microbiology. :766-773
ISSN:	2165-3410 2165-3402
DOI:	10.4236/aim.2014.412084
Popis:	One of the approaches to the treatment of infections caused by multiply-(MDR) or extra drug- resistant (XDR) pathogenic strains may be application of bacterial viruses (bacteriophages)— phage therapy. Results of a long, but quite limited use of phage therapy in several Eastern European countries, as well as experiments on animal models in Western countries support the possibility to use phage therapy. However, given the role of phages in the evolution of bacterial pathogens, it is necessary to discuss and evaluate negative consequences of mass introduction of phage therapy, as the measures necessary for its safe use. We discuss some actions in case of transiting to world-wide use of phage therapy with purpose to prolong the active life of phage therapy and to diminish possible complications.
Databáze:	OpenAIRE
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