The role of CD11c in IL-17A and IL-22 production in innate A. fumigatus infection (70.10)
| Autor: | Melissa Gessner, Lauren Lilly, Chad Dunaway, Daniel Bullard, Chad Steele |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | The Journal of Immunology. 188:70.10-70.10 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.188.supp.70.10 |
| Popis: | We have previously reported that mice deficient in the beta-glucan receptor Dectin-1 displayed increased susceptibility to A. fumigatus lung infection in the presence of lower IL-17A and IL-22 production in the lungs. Our data suggests that IL-23 contributes to most, but not all, Il-17A and IL-22. As the presence of CD11b+ and CD11c+ cells are required for optimal IL-17A production by neutrophils (Werner, et al.), we examined the role of the CD11b and CD11c receptors in lung cell production of IL-17A and IL-22 during A. fumigatus infection. Here, we show that CD11c deficiency, and CD11b deficiency to a lesser extent, results in compromised IL-17A and IL-22 production by lung cells from A. fumigatus challenge mice. We further observed a contribution for CD11c in the production of IL-1a, IL-1b and TNF-a as well as neutrophil recruitment during A. fumigatus infection. Despite impaired levels of IL-17A and IL-22, CD11c deficiency did not result in impaired Il23 mRNA levels. Collectively, our results indicate that CD11c is required for optimal IL-17A and IL-22 production in early innate lung defense against A. fumigatus, although this defect is not a result of impaired IL-23 induction. |
| Databáze: | OpenAIRE |
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