Histopathologic Evaluation of Ecballium Elaterium Applied Nasal Mucosa in Rat Rhinosinusitis Model
| Autor: | Rabia Bozdogan Arpaci, Elif Sahin Horasan, Neslihan Eti, Derya Ümit Talas, Yusuf Vayisoglu, Berkan Kardaş, Can Mehmet Eti, Arzu Kanik, Serap Yalin |
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| Rok vydání: | 2018 |
| Předmět: |
Nasal cavity
medicine.medical_specialty Soft palate biology Maximum level business.industry Elaterium Mucous membrane of nose medicine.disease biology.organism_classification Gastroenterology Ecballium elaterium medicine.anatomical_structure Otorhinolaryngology Fibrosis Internal medicine medicine business |
| Zdroj: | Ear, Nose & Throat Journal. 97:1-19 |
| ISSN: | 1942-7522 0145-5613 |
| DOI: | 10.1177/014556131809700616 |
| Popis: | This study aims to evaluate the antimicrobial effects of Ecballium Elaterium (E.E) that is topically applied for treatment of rhinosinusitis as a traditional medicine. Pure and extract forms of E.E are applied to the nasal cavity of rats for rhinosinusitis. Nasal mucosa, soft palate and trachea of rats were harvested in the first hour, 3rd day and 3rd week for histopathological evaluation. This experimental study revealed antiinflammatory effects of E.E. It has also been shown that E.E reduced fibrosis. The antiinflammatory effect of all forms of E.E has been found to be at their maximum level in the 3rd day with a decreasing manner to 3rd week. Additionally, pure form of E.E caused severe epithelial loss in hyperacute stage. E.E also reduced fibrosis besides its antiinflammatory effect. The action mechanism of antiinflammatory effect of different levels of extract forms need to be further analysed through related enzymatic pathways by different dose and time studies. |
| Databáze: | OpenAIRE |
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