The role of AKAP12 in coordination of VEGF‐induced endothelial cell motility

Autor:	Ryan Walker-Gray, Enno Klussmann
Rok vydání:	2019
Předmět:	0301 basic medicine Physiology Kinase Chemistry Protein subunit Phosphodiesterase Adenylate kinase 030204 cardiovascular system & hematology AKAP12 Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Signal transduction Protein kinase A Intracellular
Zdroj:	Acta Physiologica. 228
ISSN:	1748-1716 1748-1708
DOI:	10.1111/apha.13359
Popis:	In this issue of Acta Physiologica, Benz et al. study the role of one important protein in the cyclic AMP signaling pathway, the A-kinase anchoring (AKAP)12. The downstream effects stemming from cAMP release are tightly controlled and activate a profusion of signaling pathways. However, many of these different processes function with largely the same major constituent proteins, including adenylate cyclases, kinases, phosphatases, and phosphodiesterases. cAMP-dependent protein kinase (PKA), which is the main intracellular target for cAMP, is widely found in these signaling assemblies, and is present at high concentrations in many tissues, playing varied roles in the regulation of molecular processes. Unexpectedly, despite its ubiquity there are only four isoforms of PKA regulatory subunit with which to impart functional and locational specificity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::db4d73972759422f2723c442d5d1fab5 https://doi.org/10.1111/apha.13359 Zobrazit plný text záznamu Plný text