The Impairment of Osmoregulation in the Rat Offsprings of Hyperadiuretic Mothers Is Probably of Renal Nature2)
| Autor: | J Ponec, Srámková J, B Lichardus, A Szabóová, Horký K, Földes O |
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| Rok vydání: | 2009 |
| Předmět: |
Vasopressin
medicine.medical_specialty Pregnancy Fetus Endocrinology Diabetes and Metabolism Urinary system General Medicine Urine Biology medicine.disease Synthetic analogue Endocrinology Internal medicine Internal Medicine medicine Osmoregulation Tonicity hormones hormone substitutes and hormone antagonists |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 82:107-110 |
| ISSN: | 1439-3646 0947-7349 |
| Popis: | Experimental hyperadiuretism in pregnant rats was induced by applying them daily throughout the pregnancy a synthetic analogue of vasopressin--dDAVP (1-deamino-8-D-arginine vasopressin). It brought about a moderate alteration in the ability to produce hypertonic urine in their offsprings. The osmoregulatory function in the offsprings in the course of fetal development could have been suppressed either by a direct or an indirect effect of dDAVP i.e. by the hypotonicity of mothers' internal environment. There is by now some evidence based on the simultaneous determination of urinary vasopressin and osmolality that the impairment of the osmoregulatory function may be, at least partly, on the renal level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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