Effect of BN 52256 and Other Mediator Antagonists on Ouabain-Induced Ventricular Fibrillation in Sensitized Guinea-Pigs and on Ischemia-Induced Fibrillation in Rats

Autor:	T Rein, Braquet C, Mest Hj, A Riedel, Köpernik W
Rok vydání:	1992
Předmět:	Fibrillation medicine.medical_specialty business.industry Coronary ligation Ischemia medicine.disease Ouabain chemistry.chemical_compound Threshold dose Mediator chemistry Internal medicine Ventricular fibrillation medicine Cardiology medicine.symptom business Histamine medicine.drug
Zdroj:	Prostaglandins in the Cardiovascular System ISBN: 9783034872645
DOI:	10.1007/978-3-0348-7262-1_32
Popis:	The threshold dose of ouabain necessary to induce ventricular fibrillation is decreased in sensitized guinea-pigs signalizing an enhanced arrhythmogenicity. Esculetine or WEB 2170 antagonists of histamine and PAF, respectively and especially a combination of both can increase the threshold dose of ouabain-induced fibrillation demonstrating an antiarrhythmic effect. BN 52256 a substance with multi-antagonistic properties shows antiarrhythmic effect in this method, too. WEB 2170 and BN 52256 decrease the incidence of ventricular fibrillation after coronary ligation in rats.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::dacd13dc40bbfbb1536623469678627a https://doi.org/10.1007/978-3-0348-7262-1_32 Zobrazit plný text záznamu