Facile green route synthesis of gold nanoparticles using Caulerpa racemosa for biomedical applications
| Autor: | Sonaimuthu Mohandoss, Muthushanmugam Manikandakrishnan, Baskaran Kalanjiaraja, Ramar Manikandan, Narayanasamy Marimuthu Prabhu, Subramanian Palanisamy, SangGuan You, Mehdi Tabarsa, Manoharan Vinosha |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
biology
Chemistry Pharmaceutical Science 02 engineering and technology 021001 nanoscience & nanotechnology biology.organism_classification 030226 pharmacology & pharmacy 03 medical and health sciences Caulerpa racemosa 0302 clinical medicine Phytochemical Colloidal gold Microscopy Surface plasmon resonance 0210 nano-technology High-resolution transmission electron microscopy Antibacterial activity Human colon Nuclear chemistry |
| Zdroj: | Journal of Drug Delivery Science and Technology. 54:101345 |
| ISSN: | 1773-2247 |
| DOI: | 10.1016/j.jddst.2019.101345 |
| Popis: | A green chemical approach to the synthesis of gold nanoparticles from the Caulerpa racemosa and its biomedical applications are reported. The C. racemosa mediated synthesized gold nanoparticles (Cr@AuNPs) were characterized by various spectral and microscopy techniques. The Cr@AuNPs exhibited a surface plasmon resonance (SPR) peak at 528 nm in UV–Vis spectrum. X-ray diffraction analysis confirmed the crystalline nature and face-centered cubic (fcc) structure of Cr@AuNPs. The presence of phytochemical constituents in the aqueous extract of C. racemosa that involves the major role in Cr@AuNPs synthesis which was confirmed by FT-IR analysis. Further, FESEM and HRTEM results confirmed that the Cr@AuNPs were spherical-to-oval in shape, and the size was ranged from 13.7 to 85.4 nm. The synthesized Cr@AuNPs effectively controlled the growth of human colon adenocarcinoma (HT-29) cells, and it exhibited the IC50 at 20.84 μg/ml. Similarly, the green synthesized Cr@AuNPs demonstrated admirable antibacterial activity against A. veronii than S. agalactiae. Further, the synthesized Cr@AuNPs exhibited non-toxic effects on Artemia nauplii, even at high concentration of Cr@AuNPs (100 μg/ml). The above findings deliver a strong basis for future studies into drug development for cancer and bacteria. |
| Databáze: | OpenAIRE |
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