In vitro evaluation of mucoadhesive and self-disinfection efficiency of (acrylic acid/polyethylene glycol)-silver nanocomposites for buccal drug delivery
| Autor: | Nagwa A. Badawy, Amany I. Raafat, Amr El-Hag Ali, Ghada A. Mahmoud, Mai. F. Elshahawy |
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| Rok vydání: | 2017 |
| Předmět: |
Drug
Nanocomposite Polymers and Plastics Chemistry media_common.quotation_subject Bioengineering 02 engineering and technology Buccal administration Polyethylene glycol 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences In vitro 0104 chemical sciences Biomaterials chemistry.chemical_compound Drug delivery Materials Chemistry 0210 nano-technology Drug carrier Nuclear chemistry Acrylic acid media_common |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 33:95-115 |
| ISSN: | 1530-8030 0883-9115 |
| DOI: | 10.1177/0883911517710665 |
| Popis: | A mucoadhesive drug delivery system can improve the effectiveness of a drug, allowing targeting and localization at a specific site. According to this assumption, γ-irradiation as eco-friendly technique was employed to synthesize (acrylic acid/polyethylene glycol) copolymer hydrogel of different compositions. Silver nanoparticles were prepared within (acrylic acid/polyethylene glycol) hydrogel network by means of in situ reduction of silver nitrate using sodium borohydride as a reducing agent. Swelling characteristics in distilled water and simulated saliva solution were studied as a function of copolymer composition and preparation irradiation dose. (Acrylic acid/polyethylene glycol) hydrogels and their developed Agº nanocomposites have been characterized using scanning electron microscope, thermogravimetric analysis, transmission electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffraction. Mucoadhesive strength as well as self-disinfection efficiency expressed as antibacterial activity against different bacterial strains was evaluated. Propranolol HCl as model drug was used to evaluate the potential efficiency of the obtained (acrylic acid/polyethylene glycol)-Agº nanocomposites as mucoadhesive drug carrier. The obtained results showed that the (acrylic acid/polyethylene glycol)-Agº nanocomposites show a promising self-disinfection property, and the propranolol HCl–loaded composites were able to deliver the loaded drug in a sustainable manner that lasts for about 600 min. |
| Databáze: | OpenAIRE |
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