Increasing SBP variability is associated with an increased risk of developing incident diabetic foot ulcers
| Autor: | Meghan B. Brennan, Elbert S. Huang, Jennifer M. Lobo, Bryn L. Sutherland, Min-Woong Sohn, Elly Budiman-Mak, Nicholas V. Emanuele, Hyojung Kang, Marylou Guihan |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Physiology Vascular disease business.industry Case-control study 030209 endocrinology & metabolism Odds ratio 030204 cardiovascular system & hematology medicine.disease Diabetic foot 03 medical and health sciences 0302 clinical medicine Diabetic foot ulcer Quartile Internal medicine Diabetes mellitus Internal Medicine medicine Cardiology and Cardiovascular Medicine business Veterans Affairs |
| Zdroj: | Journal of Hypertension. 36:2177-2184 |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0000000000001783 |
| Popis: | OBJECTIVE SBP variability may be a target for mitigating end-organ damage associated with vascular disease. We evaluated the relationship between increased SBP variability and risk of incident diabetic foot ulceration. METHODS Using a nested case-control design, we followed patients diagnosed with diabetes and treated within the US Department of Veterans Affairs Healthcare system for development of a diabetic foot ulcer (event) between 2006 and 2010. Each case was randomly matched to up to five controls based on age, sex, race/ethnicity, and calendar time. SBP variability was computed using at least three blood pressure measurements from the year preceding the event. The association between SBP variability and foot ulceration was examined using conditional logistic regression. Potential protective effects of calcium channel blockers, which blunt SBP variability, were also explored. RESULTS The study sample included 51 111 cases and 129 247 controls. Compared with those in quartile 1 (lowest variability), patients in quartiles 2-4 had higher adjusted odds ratios for diabetic foot ulcer development: 1.11 (95% CI 1.07-1.16), 1.20 (95% CI 1.15-1.25), 1.29 (95% CI 1.24-1.34) (P for trend |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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