ChemInform Abstract: Mild Synthesis of Asymmetric 2′-Carboxyethyl-Substituted Fluoresceins

Autor:	Eugeny A. Lukhtanov, Alexei Vorobiev
Rok vydání:	2008
Předmět:	chemistry.chemical_compound Phthalic anhydride chemistry General Medicine Resorcinol Fluorescein Medicinal chemistry
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200830180
Popis:	Asymmetric fluoresceins bearing a carboxyethyl group in the chromophoric portion of the dyes were prepared by a reaction of substituted phthalic anhydride with a carboxyethyl substituted resorcinol analogue followed by a condensation with a second resorcinol analogue. In order to avoid an accumulation of symmetric side products, the second step was performed in two substeps: acid-catalyzed formation of a triphenylmethyl intermediate followed by base-catalyzed cyclization which furnished the desired dyes.
Databáze:	OpenAIRE
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