Cantharidin derivatives from the medicinal insect Mylabris phalerata
| Autor: | Wei Zhang, Wen-Cai Ye, Lei Wang, Xueping Lei, Xue-Ying Gong, Ni-Ping Li, Yuan-Yuan Deng, Dong-Mei Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Cantharidin
biology 010405 organic chemistry Stereochemistry Chemistry media_common.quotation_subject Organic Chemistry Insect Nuclear magnetic resonance spectroscopy biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Adduct 03 medical and health sciences Neutral Amino Acids chemistry.chemical_compound 0302 clinical medicine 030220 oncology & carcinogenesis Drug Discovery Ic50 values Organic chemistry Mylabris phalerata media_common |
| Zdroj: | Tetrahedron. 73:5932-5939 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2017.08.034 |
| Popis: | Thirteen new cantharidin derivatives including six cantharimide-amino acid adducts (1–6), five cantharimide dimers (7–11) and two cantharimide-aromatic compound hybrids (12–13) were isolated from Mylabris phalerata Pallas. Compounds 1–5 represent the first natural products combined through cantharimide and neutral amino acids. Compounds 7–11 are the first cantharimide dimers consisting of two different cantharimide cores. Their structures with absolute configurations were elucidated by means of NMR spectroscopy, single-crystal X-ray diffraction, and semi-synthesis. Compound 6 showed weak cytotoxicity against HepG2, A549 and MDA-MB-231 cells with IC50 values of 15.70 ± 3.06, 20.67 ± 4.05 and 23.79 ± 4.54 μM, respectively. |
| Databáze: | OpenAIRE |
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