A Novel Benzodiazepine Partial Inverse Agonist, S-8510, as a Cognitive Enhancer

Autor:	Tsuyoshi Kihara, Masato Ikeda, Masami Eigyo, Susumu Takada, Shunji Murata, Kazuo Kawasaki, Katsumi Koike
Rok vydání:	1996
Předmět:	Benzodiazepine business.industry medicine.drug_class Hippocampus Long-term potentiation Pharmacology Convulsion Extracellular Medicine Inverse agonist Cholinergic medicine.symptom business Acetylcholine medicine.drug
Zdroj:	GABA: Receptors, Transporters and Metabolism ISBN: 9783034898584
DOI:	10.1007/978-3-0348-8990-2_28
Popis:	Pharmacological actions of a novel benzodiazepine partial inverse agonist, S-8510 were examined. S-8510 ameriolated memory impairment induced by cholinergic deficit in rats in addition to augmentation of the LTP in hippocampal slice preparation. Furthermore, S-8510 increased in the extracellular level of acetylcholine in the hippocampus. S-8510 selectively potentiated pentylenetetrazol-induced convulsion without affecting minimum electrical shock- or strychnine-induced convulsion in mice. These results suggest that S-8510 is a therapeutic drug for senile dementia, including Alzheimer’s disease with little risk for inducing anxiety or convulsion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d996bebc7280822111eb2d137c964321 https://doi.org/10.1007/978-3-0348-8990-2_28 Zobrazit plný text záznamu