Potent anti-adhesion agent using a drug-eluting visible-light curable hyaluronic acid derivative
| Autor: | Seung-Hyun Noh, Tae-Il Son, Young-Gi Lee, Mi Kyung Kim, Yoshihiro Ito, Eui-Chan Jang, Jae-Won Kim, Ga-Dug Han, Jae-Woon Nah, Shin-Woong Kim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
Chemistry General Chemical Engineering media_common.quotation_subject 02 engineering and technology Adhesion 010402 general chemistry 021001 nanoscience & nanotechnology Ibuprofen 01 natural sciences Isocyanate Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Hyaluronic acid medicine Anti-Adhesion Agent Moiety 0210 nano-technology Derivative (chemistry) media_common medicine.drug |
| Zdroj: | Journal of Industrial and Engineering Chemistry. 70:204-210 |
| ISSN: | 1226-086X |
| DOI: | 10.1016/j.jiec.2018.10.017 |
| Popis: | Post-operative adhesion is a very serious complication in the clinical field, frequently occurring after surgery. In severe cases, reoperation may be required. In this study, a visible light-curable furfuryl hyaluronic acid derivative was prepared and combined with ibuprofen for anti-adhesion and anti-inflammatory applications. A furfuryl isocyanate moiety was introduced in hyaluronic acid affording furfuryl hyaluronic acid (F-HA). The anti-adhesion and anti-inflammatory effects of F-HA were examined in chickens at 2, 4, and 8 weeks postoperation. It was concluded that F-HA combined with ibuprofen is a suitable anti-adhesion and anti-inflammation agent. |
| Databáze: | OpenAIRE |
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