Asymmetric Dimethylarginine Contributes to Airway Nitric Oxide Deficiency in Patients with Cystic Fibrosis
| Autor: | Jaques Belik, Suhail Al-Saleh, Jeremy A. Scott, Reshma Amin, Hartmut Grasemann, Mahroukh Rafii, Felix Ratjen, Darakhshanda Shehnaz, Paul B. Pencharz, Anne Mehl |
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| Rok vydání: | 2011 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Pancreatic disease Arginine business.industry Critical Care and Intensive Care Medicine medicine.disease Cystic fibrosis Nitric oxide Arginase chemistry.chemical_compound Endocrinology chemistry Internal medicine Intensive care medicine Sputum medicine.symptom Asymmetric dimethylarginine business |
| Zdroj: | American Journal of Respiratory and Critical Care Medicine. 183:1363-1368 |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/rccm.201012-1995oc |
| Popis: | Rationale: Airway nitric oxide is reduced in cystic fibrosis airways. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that may contribute to nitric oxide deficiency in cystic fibrosis.Objectives: To test the hypothesis that asymmetric dimethylarginine is increased in cystic fibrosis and contributes to nitric oxide deficiency and airway obstruction.Methods: The concentrations of asymmetric dimethylarginine, symmetric dimethylarginine, and l-arginine were measured in sputum of clinically stable patients with cystic fibrosis, in patients with cystic fibrosis before and after treatment for a pulmonary exacerbation, and in healthy control subjects, using liquid chromatography-tandem mass spectrometry.Measurements and Main Results: Asymmetric dimethylarginine was increased in cystic fibrosis compared with control sputum, and the l-arginine/asymmetric dimethylarginine ratio was decreased. Symmetric dimethylarginine exceeded asymmetric dimethylarginine concentrations in control sputum... |
| Databáze: | OpenAIRE |
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