The Role of the Hepatic Tissue Remodeling Regulators MMP-9 and TIMP-1 in the Progression of Liver Cirrhosis

Autor:	A. E. Kozlov, D. V. Tereshkov, A. N. Lyzikov, A. G. Skuratov, O. V. Osipkina, A. N. Kondrachuk, E. V. Voropaev, N. M. Golubykh, M. N. Yatsuk
Rok vydání:	2019
Předmět:	Pathology medicine.medical_specialty Cirrhosis genetic structures business.industry medicine Hepatic tissue Matrix metalloproteinase medicine.disease business
Zdroj:	Health and Ecology Issues. :88-94
ISSN:	2708-6011 2220-0967
DOI:	10.51523/2708-6011.2019-16-4-18
Popis:	Objective: to study the level of the hepatic tissue remodeling regulators MMP-9 and TIMP-1 in the blood of patients with the progression of chronic diffuse liver diseases.Material and methods. The object of the study was 80 patients with chronic diffuse liver diseases (chronic hepatitis and cirrhosis). The concentration of MMP-9 and TIMP-1 in the blood of the patients was determined by enzymelinked immunosorbent assay (ELISA).Results: As chronic diffuse liver diseases progressed, a statistically significant decrease in the level of MMP-9 in the blood of the patients was revealed, which was reflected in the decreased intensity of the extracellular matrix resorption processes and transformation of chronic hepatitis into liver cirrhosis. The activity of TIMP-1 which suppressed the fibrolytic effects of MMP-9, was statistically significantly higher in the viral etiology of liver cirrhosis, which probably led to more rapid progression of liver fibrosis associated with the presence of hepatitis C and В viruses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d8cb5183674c81c7cb81fd22918d5902 https://doi.org/10.51523/2708-6011.2019-16-4-18 Zobrazit plný text záznamu