Formulation of Sustained-Release Matrix Tablet of Rotundin Sulfat

Autor: Do Thi Ha, Tran Thi Van Anh, Nguyen Thanh Hai, Ha Thanh Hoa, Pham Thi Minh Hue
Rok vydání: 2019
Předmět:
Zdroj: VNU Journal of Science: Medical and Pharmaceutical Sciences. 35
ISSN: 2588-1132
2615-9309
DOI: 10.25073/2588-1132/vnumps.4172
Popis: Sustained-release matrix tablets containing rotundin sulfat are prepared by a wet granulation method. The influence of Metholose 100.000 RS, 4000 SR, Avicel PH101, lactose and tablet compression force on the ability to release rotundin from the tablets has been evaluated. Modde 8.0 software was used in the experiment. The influencing factors were evaluated by software FormRules v2.0 and the optimal formula predicted by the INForm v3.1 was optimized. The selected optimal formulation of rotundin sulfate tablets for a drug release process lasting 8 hours contained Metholose 100.000 RS 120 mg; Avicel PH101 24.0 mg; lactose 34.5 mg; and 8 kP tablet hardness. Keywords Rotundin sulfat, matrix tablet, sustained release, optimizing. References [1] Đỗ Tất Lợi, Những cây thuốc và vị thuốc Việt Nam, NXB Thời Đại (2011), 779. [2] Nguyễn Minh Chính và CS, Nghiên cứu tách chiết rotundin để sản xuất thuốc tiêm rotundin sulfat, Tạp chí Y Dược học Quân sự. 1 (1999) 55-56. [3] Nguyễn Thanh Hải, Bùi Thanh Tùng, Phạm Thị Minh Huệ (2017), Phỏng sinh học trong y dược học – Hướng nghiên cứu cần đẩy mạnh, Tạp chí khoa học ĐHQGHN, Khoa học Y Dược. 33(1) (2017) 1-4. [4] Bộ Y tế, Dược điển Việt Nam V, Nhà xuất bản Y học, 1 (2017), 842-844. [5] M. Levina, A.R. Rajabi-Siaboomi, The influence of excipients on drug release from hydroxypropyl methylcellulose matrices, Journal of Pharmaceutical Sciences. 93(11) (2004) 2746-2754. [6] Nguyễn Minh Chính, Nguyễn Thị Hồng Thắm, Nguyễn Văn Bạch, Tối ưu hóa công thức bào chế viên nén rotundin sulfat giải phóng kéo dài, Tạp chí Y Dược học Quân sự. số CĐ Dược (2016), 61-67. [7] N. Aruna, K.M. Babu, Formulation and evaluation of sustained release matrix tablets containing metformin HCl and Syzygium cumini, International Journal of Pharmaceutical and Biological Archive. 2(3) (2011), 900-905. [8] B.J. Lee, et al, Formulation and release charecteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin, Drug Development and Industrial Pharmacy. 25 (1999) 493-501.[9] A. Nokhochi, J.L. Ford, P. Rowe, et al, The e ffects of compression rate and force on the compaction properties of different viscosity grades of hydroxypropyl methylcellulose 2208, International Journal of Pharmaceutics. 129 (1996), 21-31.
Databáze: OpenAIRE
Externí odkaz: