Homozygous Prothrombin Gene Mutationand Ischemic Cerebrovascular Disease

Autor:	Achille Iolascon, B Coppola, Paola Giordano, Domenico De Lucia
Rok vydání:	1999
Předmět:	medicine.medical_specialty Vascular disease business.industry Prothrombin gene mutation Hematology General Medicine medicine.disease Thrombophilia Thrombosis Surgery Pathogenesis Central nervous system disease Internal medicine medicine Cardiology Coagulopathy Superficial thrombophlebitis business
Zdroj:	Acta Haematologica. 102:101-103
ISSN:	1421-9662 0001-5792
DOI:	10.1159/000040979
Popis:	We report the case of a 31-year-old woman who, at the age of 26 suffered from an episode of superficial thrombophlebitis in the left leg, experienced two episodes of transient ischemic attacks at the age of 30 and had an ischemic stroke with left-sided hemiparesis at the age of 31 years. A cerebral CT scan showed an ischemic lesion in the right sylvian area involving the opercular and nucleocapsular regions. Her father had had an ischemic stroke at the age of 54 years and died at the age of 58; her mother had had a myocardial infarction at the age of 48 years and died at 51 years from breast cancer. Laboratory investigation of the patient demontrated high levels of fibrinogen, F II, F VII, F 1 + 2, FPA and ACA-IgG with low levels of HDL cholesterol associated with homozygosity for the 20210 A genotype. There were no other genetic or acquired prothrombotic defects. In conclusion, this case strongly suggests a clinically significant role ot the prothrombin gene mutation in both arterial and venous thrombosis.
Databáze:	OpenAIRE
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