Pelvic floor muscle training in the treatment of pelvic organ prolapse: A meta-analysis of randomized controlled trials

Autor: Hong-Zhen Zhang, X.J. Wei, Jing Ge, Guiying Fang
Rok vydání: 2021
Předmět:
Zdroj: Actas Urológicas Españolas (English Edition). 45:73-82
ISSN: 2173-5786
DOI: 10.1016/j.acuroe.2020.12.002
Popis: Background We aimed to assess the overall effect of pelvic muscle training (PFMT) on patients with pelvic organ prolapse (POP) based on eligible randomized controlled trials (RCT). Methods We searched the following databases, such as PubMed, Cochrane, and Embase, to identify eligible RCT based on the index words updated to December 2018. We also searched the publications related to the present study. Odds rations (OR), and mean difference (MD) along with 95% confidence interval (95%CI) were used to analyze the main outcomes. Results In this meta-analysis, 15 RCTs were included with a total of 1309 patients in the PFMT group and a total of 1275 patients in the control group. The overall results showed no significant difference in the incidence of add 2 POP-Q stages (RR: 0.55, 95%CI: 0.19–1.63), add 1 POP-Q stages (RR: 1.04, 95%CI: 0.69–1.57), no POP-Q stages change (RR: 0.94, 95%CI: 0.81–1.09), reduce 2 POP-Q stages (RR: 1.72, 95%CI: 0.79–3.76), self-reported same symptom change (RR: 0.70, 95%CI: 0.45–1.09), and self-reported worse symptom change (RR: 0.67, 95%CI: 0.22–2.03) between the 2 groups. Besides, the incidence of reduce 1 POP-Q stages was significantly higher in the PFMT group than that of the control group (RR: 1.80, 95%CI: 1.20–2.69), and the PFMT significantly changed the self-reported symptoms with better outcomes when compared with the control group (RR: 2.90, 95%CI: 1.72–4.89). However, after the therapy, the PFMT group decreased the POP-SS (SMD: −0.24, 95%CI: −0.71 to 0.22), POPDI-6 (SMD: −0.14, 95%CI: −0.43 to 0.15), CRADI-8 (SMD: −0.03, 95%CI: −0.16 to 0.11), and UDI-6 (SMD: −0.17, 95%CI: −0.43 to 0.10) versus the control group, but without statistical significance. Conclusion PMFT showed better effect in reducing 1 POP-Q stages, changing the self-reported symptoms with better outcomes, decreasing the score of POP-SS, POPDI-6, CRADI-8, and UDI-6 in women with POP versus the control group. However, more high-quality multicenter RCTs with a larger sample size are needed to confirm the present conclusions.
Databáze: OpenAIRE
Externí odkaz: