Electrical Conductivity and Cholinergic Activity of the Rat Gastric Mucosa, At 4 and 170 Hours after 600 R X-Irradiation
| Autor: | Rita L. Pessotti, Burton E. Vaughan |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Pathology
medicine.medical_specialty Radiation Chemistry Biophysics Depolarization Conductivity Type (model theory) medicine.anatomical_structure Electrical resistivity and conductivity Gastric mucosa medicine Radiology Nuclear Medicine and imaging Irradiation Incubation Acetylcholine medicine.drug Nuclear chemistry |
| Zdroj: | Radiation Research. 48:116 |
| ISSN: | 0033-7587 |
| DOI: | 10.2307/3573400 |
| Popis: | Gastric mucosas were prepared for incubation from excised whole stomachs of irradiated and nonirradiated rats. Measurements were made of transmucosal potential, direct current conductivity, and acetylcholine (ACh) response. When suitably prepared, the mucosa showed low conductivity values of $12\ {\rm mmho}/{\rm cm}^{2}$ . Conductivity increased markedly after imposing brief electric shock $8\ {\rm mA}/{\rm cm}^{2}$ or after metabolic inhibition (nitrogen). The response, in both cases, was like a depolarization, with the potential decreasing concomitantly. After irradiation, a different type of response occurred after 4 hours and after 170 hours. After 4 hours, the potential was elevated 40% above that of the nonirradiated control, with negligible change in conductivity. No significant change was detected in reactivity toward 10-3 M ACh (added to the baths). After 170 hours, the potential was identical to that of the nonirradiated control, but conductivity showed a... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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