Intracellular Partition of Plasma Glucose Disposal in Hypertensive and Normotensive Subjects with Type 2 Diabetes Mellitus1
| Autor: | Riccardo C. Bonadonna, Maria Alberiche, F. Saggiani, Michele Muggeo, Giovanni Targher, Enzo Bonora, M. Zenere |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
biology business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry Type 2 Diabetes Mellitus Metabolism medicine.disease Essential hypertension Biochemistry Endocrinology Insulin resistance Basal (medicine) Internal medicine biology.protein Medicine business Glycogen synthase Pancreatic hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 86:2073-2079 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.86.5.7455 |
| Popis: | The aim of this study was to ascertain whether the presence of hypertension conveys a more severe degree of insulin resistance in type 2 diabetes mellitus and, if so, which biochemical pathways are involved. We quantitated the rates of total glucose disposal, glycogen synthesis (GS), glycolysis, glucose oxidation, endogenous glucose production, and LOX in the basal state and during a 4-h euglycemic (∼5 mm) hyperinsulinemic (∼300 pm) clamp carried out in combination with a dual-tracer infusion ([3H]-3- and [14C]-U-d-glucose) and indirect calorimetry in 42 nonobese noninsulin-treated type 2 diabetic subjects (22 hypertensive and 20 normotensive) and 23 nonobese nondiabetic subjects (9 without and 14 with essential hypertension). Compared with normotensive controls, both groups of diabetic subjects were markedly insulin resistant. In the basal state, all glucose fluxes were similar in diabetic subjects with or without hypertension. During insulin infusion, total glucose disposal was significantly reduced in ... |
| Databáze: | OpenAIRE |
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