Hepatic vascular inflow occlusion enhances tissue destruction during cryoablation of porcine liver1

Autor:	Lars Frich, Ole Petter F. Clausen, Lars Aurdal, Ivar P. Gladhaug, Odd Søreide, Bjørn Edwin, Tom Mala
Rok vydání:	2003
Předmět:	Pathology medicine.medical_specialty medicine.diagnostic_test business.industry medicine.medical_treatment Cryotherapy Magnetic resonance imaging Cryoablation Ablation Cryosurgery Porcine liver Occlusion medicine Surgery Inflow occlusion business human activities
Zdroj:	Journal of Surgical Research. 115:265-271
ISSN:	0022-4804
DOI:	10.1016/j.jss.2003.07.009
Popis:	Background Local recurrences after cryoablation of liver tumors have been reported at rates from 5% to 44% and can be caused by inadequate coverage of the tumor by the frozen region. Hepatic vascular inflow occlusion may facilitate ablation by enlarging the size of the frozen region and the tissue necrosis induced by freezing. Few studies have documented these effects of inflow occlusion during liver cryoablation. Materials and methods Two cryolesions were induced in the liver of 12 pigs in a standardized set-up. Vascular inflow occlusion was used in six pigs during freezing. Two freeze cycles were performed at each location. Ice-ball volume was estimated by intraoperative magnetic resonance imaging. Cryolesion volume was estimated from histopathologic examination of the lesions 4 days after ablation. Results The median volume of ice-balls produced during inflow occlusion was 107% larger than for ice-balls produced without occlusion (P Conclusions Hepatic vascular inflow occlusion enables freezing of larger volumes of liver tissue andincreases the volume of tissue necrosis induced during cryoablation of porcine liver.
Databáze:	OpenAIRE
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