A novel oxidatitive rearrangement of a pentasubstituted pyrrole to an unsaturated hydroxy γ-lactam

Autor:	Rona M. Highcock, Panayiotis A. Procopiou
Rok vydání:	1994
Předmět:	chemistry.chemical_compound Nitrile Chemistry Stereochemistry X-ray crystallography Lactam Molecule Propionitrile Crystal structure Medicinal chemistry Isopropyl Pyrrole
Zdroj:	J. Chem. Soc., Perkin Trans. 1. :245-247
ISSN:	1364-5463 0300-922X
Popis:	Treatment of a pentasubstituted bromopyrrole with N-bromosuccinimide resulted in a novel oxidative rearrangement involving insertion of oxygen, debromination and migration of an isopropyl group to give 3-[2-(4-fluorophenyl)-1,5-dihydro-2-hydroxy-4-isopropyl-5-oxo-3-(4-pyridyl)-1H-pyrrol-1-yl] propionitrile, an X-ray crystallographic structural determination of which is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::d80492362f4140aa467bba94a0044f80 https://doi.org/10.1039/p19940000245 Zobrazit plný text záznamu