Cytotoxic Monoterpenoid Indole Alkaloids from Tabernaemontana corymbosa as Potent Autophagy Inhibitors by the Attenuation of Lysosomal Acidification
| Autor: | Ling-Li Guo, Yu-Xi Yuan, Xiao Ding, Yu Zhang, Xiao-Jiang Hao |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
Circular dichroism Monoterpenoid Indole Alkaloids biology Chemistry Stereochemistry Organic Chemistry Autophagy Pharmaceutical Science Nuclear magnetic resonance spectroscopy biology.organism_classification Mass spectrometry Analytical Chemistry Complementary and alternative medicine Drug Discovery Molecular Medicine Cytotoxic T cell Tabernaemontana corymbosa |
| Zdroj: | Journal of Natural Products. 83:1432-1439 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/acs.jnatprod.9b00856 |
| Popis: | Twenty-six alkaloids, including the new taberines A–I (1–9), were obtained from Tabernaemontana corymbosa. The structures and absolute configurations were elucidated via MS, NMR, and ECD spectrosco... |
| Databáze: | OpenAIRE |
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