Spectrophotometric Determination of Oxamniquine via Charge Transfer Complex Formation with Iodine

Autor:	F. I. Khattab, A. K. S. Ahmad, N. A. El Ragehy, M. F. El Tarras
Rok vydání:	1991
Předmět:	medicine.diagnostic_test Chemistry Analytical chemistry chemistry.chemical_element Charge-transfer complex Iodine Acceptor Atomic and Molecular Physics and Optics Analytical Chemistry Oxamniquine Solvent Absorbance Spectrophotometry medicine Spectroscopy Stoichiometry medicine.drug
Zdroj:	Spectroscopy Letters. 24:81-97
ISSN:	1532-2289 0038-7010
DOI:	10.1080/00387019108018126
Popis:	In this work the reaction between oxamniquine as n donor and iodine as sigma acceptor was studied,. Different parameters involved in the reaction were investigated such as choice of solvent, iodine concentration, time, light and temperature. Also the stoichiometry of the reaction was determined. Thus, a spectrophotometric procedure has been developed for the determination of oxamniquine by reaction with iodine and measurement of absorbance of the formed charge transfer complex at λ 291 and λ 360 nm. Molar absorptivities, A 1%, 1 cm and the regression equations were computed. The proposed procedure was applied for the determination of oxamniquine in its dosage forms. Accurate and precise results were obtained when compared to the manufacturer's procedure.
Databáze:	OpenAIRE
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