Increased Prevalence of Infectious Diseases and Other Adverse Outcomes in Human T Lymphotropic Virus Types I‐ and II‐Infected Blood Donors
| Autor: | Simone A. Glynn, Edward L. Murphy, Dannie I. Ameti, Catharie C. Nass, David Wright, George B. Schreiber, George J. Nemo, Joan Gibble, James W. Smith, Bruce Newman, Joy Fridey, Ronald A. Sacher |
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| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Tuberculosis biology business.industry Odds ratio Human T-lymphotropic virus biology.organism_classification medicine.disease Pneumonia Infectious Diseases Human T-lymphotropic virus 1 Internal medicine Immunology Human T-lymphotropic virus 2 medicine Immunology and Allergy Viral disease business Kidney infection |
| Zdroj: | The Journal of Infectious Diseases. 176:1468-1475 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/514143 |
| Popis: | Disease associations of human T lymphotropic virus types I and II (HTLV-I and -II) infection were studied in 154 HTLV-I-infected, 387 HTLV-II-infected, and 799 uninfected blood donors. Adjusted odds ratios (ORs) and 99% confidence intervals (CIs) were derived from logistic regression models controlling for demographics and relevant confounders. All subjects were human immunodeficiency virus type 1-seronegative. HTLV-II was significantly associated with a history of pneumonia (OR, 2.6; 99% CI, 1.2-5.3), minor fungal infection (OR, 2.9; 99% CI, 1.2-7.1), and bladder or kidney infection (OR, 1.6; 99% CI, 1.0-2.5) within the past 5 years and with a lifetime history of tuberculosis (OR, 3.9; 99% CI, 1.3-11.6) and arthritis (OR, 1.8; 99% CI, 1.2-2.9). Lymphadenopathy (> or =1 cm) was associated with both HTLV-I (OR, 6.6; 99% CI, 2.2-19.2) and HTLV-II (OR, 2.8; 99% CI, 1.1-7.1) infection, although no case of adult T cell leukemia/lymphoma was diagnosed. Urinary urgency and gait disturbance were associated with both viruses. This new finding of increased prevalence of a variety of infections in HTLV-II-positive donors suggests immunologic impairment. |
| Databáze: | OpenAIRE |
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