Beta sub 2 sub -adrenergic receptor variants in children and adolescents with bronchial asthma
| Autor: | Manal S. Fawzy, Ahmed Ibrahim, Nouran B. AbdAllah, Ali Kishk, Eman Mohammad, Mohammad H. Hussein, Eman A. Toraih |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
General Immunology and Microbiology business.industry Haplotype Adrenergic Adrb2 gene medicine.disease General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine B2 receptor Polymorphism (computer science) 030220 oncology & carcinogenesis Immunology medicine Receptor business Gene Asthma |
| Zdroj: | Frontiers in Bioscience. 11:61-78 |
| ISSN: | 1945-0508 1945-0494 |
| Popis: | The region encoding the N-terminal of human β2-adrenergic receptor gene (ADRB2) shows several polymorphisms. To this end, we studied change in susceptibility and/or response to therapy in 175 asthmatic children and adolescents by the two most common variants of the ADRB2 gene namely, rs1042713 (Gly16Arg) and rs1042714 (Gln27Glu). Although, the variants did not correlate with risk of development nor with the severity of the asthma, Gly16/Glu27 haplotype in homozygous individuals conferred protection against development of asthma and was associated with a lower frequency of dyspnea and sputum production. In contrast, the Arg16/Gln27 haplotype was associated with a better response to treatment. These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in ADRB2 gene. |
| Databáze: | OpenAIRE |
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