Comparison of standard and delayed imaging to improve the detection rate of [68Ga]PSMA I&T PET/CT in patients with biochemical recurrence or prostate-specific antigen persistence after primary therapy for prostate cancer
| Autor: | Tobias L. Ross, Christoph-A. von Klot, Stefan Nordlohne, Hans-Jürgen Wester, Hans Christiansen, Thorsten Derlin, Frank M. Bengel, Jan M Sohns, Christoph Henkenberens, Sebastian Schmuck |
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| Rok vydání: | 2017 |
| Předmět: |
Biochemical recurrence
PET-CT business.industry Context (language use) General Medicine medicine.disease 030218 nuclear medicine & medical imaging Persistence (computer science) 03 medical and health sciences Prostate cancer Prostate-specific antigen 0302 clinical medicine medicine.anatomical_structure Antigen 030220 oncology & carcinogenesis medicine Abdomen Radiology Nuclear Medicine and imaging Nuclear medicine business |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 44:960-968 |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | The aim of this study was to assess the value of dual-time point imaging in PET/CT for detection of biochemically recurrent or persistent prostate cancer, using the prostate-specific membrane antigen (PSMA) ligand [68Ga]PSMA I&T. 240 patients who underwent a [68Ga]PSMA I&T PET/CT in the context of biochemical relapse of prostate cancer were included in this retrospective analysis. Imaging consisted of a standard whole-body PET/CT (1 h p.i.), followed by delayed (3 h p.i.) imaging of the abdomen. PSA-stratified proportions of positive PET/CT results, standardized uptake values and target-to-background ratios were analyzed, and compared between standard and delayed imaging. The overall detection rates of [68Ga]PSMA I&T PET/CT were 94.2, 71.8, 58.6, 55.9 and 38.9% for PSA levels of ≥2, 1 to 0.2 to |
| Databáze: | OpenAIRE |
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